Description
Product Characteristics: Recombinant Pyruvate Dehydrogenase Kinase Isozyme 1 (PDK1), Prokaryotic expression, Val172-Pro399 (Accession # Q8BFP9), N-terminal His Tag
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Target Information: Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. [provided by RefSeq, Jul 2008]